The prospect of using cell-based interventions to treat neurological conditions raises several important ethical and policy questions. In this target article, we focus on issues related to the unique constellation of traits that characterize CBIs targeted at the central nervous system. In particular, there is at least a theoretical prospect that these cells will alter the recipients' cognition, mood, and behavior—brain functions that are central to our concept of the self. The potential for such changes, although perhaps remote, is cause (...) for concern and careful ethical analysis. Both to enable better informed consent in the future and as an end in itself, we argue that early human trials of CBIs for neurological conditions must monitor subjects for changes in cognition, mood, and behavior; further, we recommend concrete steps for that monitoring. Such steps will help better characterize the potential risks and benefits of CBIs as they are tested and potentially used for treatment. (shrink)

Монография предназначена для студентов, аспирантов, преподавателей юридических и философских факультетов, а также для всех тех, кто интересуется философско-правовой проблематикой.

First Criticism of the Theory.—This is of the nature of an argumentum ad hominem. In the first place, It is surprising that so clever a man as Protagoras did not see that he proved more than he intended, for according to his theory not only are all men, the wise and the foolish, reduced to the same level, but on the plane of sentient experience it is just as true to say that a pig or a tadpole is the measure (...) of all things. (shrink)

Книга предназначена для студентов, преподавателей и научных сотрудников высших учебных заведений, занимающихся вопросами современных философско-антропологических концепций.

Antiphon's speech on the murder of Herodes has been variously dated by several scholars, but all seem to agree that it was delivered a good many years after the revolt and recapture of Mytilene. According to this opinion the speaker in § 74 declares himself too young to know much of what happened in those days. Before going into this more carefully, it seems necessary to visualize the situation of the accused man. In order to achieve this the best we (...) can do is to follow his own words in the Sirjyrjcris, §§ 20–24: ‘I travelled from Mytilene on the same ship as the lost man; we were on our journey to Ainos, I to see my father—he happened to be there at that time—he in order to sell some slaves to Thracian natives. These natives, who were to pay the ransom, and the slaves were on board too.—All this I will prove by witnesses.—As we, however, met with stormy weather, we were compelled to put in to a harbour in the territory of Methymna; there we found that* ship into which Herodes changed; in that ship, according to the accusers, he died. Now all this was mere chance: obviously I had not persuaded him to travel with me, no, he was travelling on his own business. Then I, personally, had a very good reason for travelling to Ainos; our putting in to that harbour was not premeditatd, we were compelled to. And again, when we were lying at anchor, the change of ship took place without any trickery or fraud: again, it was done because of necessity. The ship, viz., on which we had been travelling was not covered, the other one on the contrary had a covering; that was because of the rain.—All this I will prove by witnesses.—After boarding the other ship we drank some wine. After that it is only known that he left the ship, but did not return. I myself never left the ship that night at all. When the next day but did not return. I myself never left the ship that night at all. When the next day he had disappeared, we looked for him, I as well as the others. Probably it seemed strange to them, it certainly did to me. And it was I who caused a messenger to be sent to Mytilene, not one of the crew or the passengers belonging to Herodes, but my own servant. If I had been guilty, I would not, of course, have sent a man who might have informed against me. But when the man could not be found in Mytilene, nor anywhere else, and when the weather had improved and all the other ships were putting out, I also sailed.—All this I will prove by witnesses. (shrink)

An edition of the letters of Erasmus, regarded as one of the greatest humanist writers. All 12 volumes of this work have been reissued, complete with their scholarly apparatus of commentary and notes, as well as plates.

The role of emotions in ethics is often taken by philosophers and others as antithetical to rationality. On the most basic level (in undergraduate philosophy exams and elsewhere), stating an opinion in the form "I feel that p" can be a way of sidestepping the demand for reasons. But emotions can sometimes also be seen as supplying reasons for moral judgment to the extent that they involve evaluations--and a way of communicating them across different moral perspectives.

Minorities who disagree with the “scientific consensus” must be allowed to air their viewsI will begin by discussing the example used in Schüklenk’s paper1 of the self proclaimed “HIV dissidents” and then discuss whether the recommendations made are useful and could be applied to other examples in science.Schüklenk’s primary concern according to his title is with the professional responsibilities of biomedical scientists engaging in public discourse. The example given is of the effect that self proclaimed HIV dissidents have had on (...) the provision of HIV related public health measures in South Africa. Fundamental to the example given is a distinction that both Schüklenk and indeed the general public often fail to make. It is important to recognise the difference between biomedical science and clinical practice. Science and medicine are two distinct fields, each with their own historically founded methods and purposes; they have had little in common with each other until relatively recently. Schüklenk confuses the two when he judges a scientific hypothesis by its clinical utility."It certainly seemed prudent to me at the time to give support to critics of a hypothesis, the pursuit of which had done little to bring those in need closer to life extending or life saving AIDS drugs."He later reconsiders his position on the basis of new clinical evidence."My own conversion to the mainstream view took place roughly when dissident predictions about AIDS deaths resulting from what they believed were highly poisonous drug cocktails—that is, triple therapy, did not occur, and when it became clear that actually the opposite was true; these drugs were at least life extending. I saw … ". (shrink)